Please include more information.
Which driver do you currently have installed?
Did you perform a clean uninstall when switching between Beta and the current 3.15.3 driver?
http://www.3dconnexion.com/faq/28
Try the below steps after performing a clean install.
The 3Dconnexion plug-in in Maya depends on the command MagellanStartup being executed by the usersetup.mel. When another script or add-in is installed it can overwrite the 3Dconnexion usersetup.mel.
To confirm this is the problem you are seeing, type "MagellanStartup" [ without the quotes ] at the Maya command line. This should enable navigation. If it does not, it will generate an error that will let us know what the problem is.
If your 3Dconnexion device starts when you type "MagellanStartup" at the command prompt but is not auto-starting, that would indicate the MagellanStartup; command needs to be added to your active usersetup.mel.
Maya will only load the first usersetup.mel it finds. If you have other scripts or add-ins such as Maya's Bonus Tools or GoZ , they add their own usersetup.mel files. To find which version of usersetup.mel Maya is using , at the Maya command line type
whatIs userSetup.mel
Open the usersetup.mel and add the line MagellanStartup; at the end. If you do not have any versions of usersetup.mel, you can create one - a plain text file with a single line
MagellanStartup;
If you are still seeing a problem, please let us know whether MagellanStartup enables navigation and any messages displayed in the Maya console