You create a new profile by launching the 3Dconnexion Properties GUI. This can normally be done from the Menu button on your device or from the systray icon, or 3DxHome (on your desktop).
There is a documentation link in 3DxHome. Let us know if the documentation needs more information.
The Manage Profiles... button in the 3Dconnexion Properties GUI will allow you to make new profiles.
Didn't you post something about this in one of the forums before the beta came out? I've kept you in mind.
This is a popular request. We have something we are playing with. The more interest we get, the more time we will put into it.
The "Default" profile (Desktop.xml) is special. It can be modified to be used regardless of which application has focus. You can then assign Mouse X/Y/Wheel and Left/Middle/Right Mouse buttons to your device by editing that profile and use your 3D mouse exactly as a 2D mouse. You could also assign all sorts of Desktop-type things in there, like Alt-Tab...
There is a specific function that you can assign to a button, named "Toggle 2D Mouse Mode" and is usually in the "Other" category. If you assign that to a device button you can toggle in and out of this mode where only the Default profile is used.
The idea is that you could enter this mode, mouse over to an application, hit the left mouse button assigned key, then do your 3D things, then toggle back to 2D mouse mode and go over to another application...
There is a possibly not so obvious issue. You have to have that Toggle 2D Mouse Mode function assigned in every application you enter or you won't be able to get back to 2D Mouse Mode <G> I always assign it to the same button so I can just toggle with that button.
The other issue is that you may have to bounce 3DxService after you make your initial changes to the Default profile.
There is no guarantee as to how well this works, nor what we will do with it in the future. It all (as everything) depends on how much interest we get.